The final presidential debate on Wednesday could be the last chance for Republican Donald Trump to shake up the dynamics of a race that's tilting toward Democrat Hillary Clinton.

Flush with fundraising cash and rising poll numbers, Clinton has largely vanished from the campaign trail as Trump deals with the latest chaos rocking his campaign.

The fallout from his incendiary remarks in the “Access Hollywood” videotape prompted a string of women to come forward with claims he sexually harassed or assaulted them – and dozens of high-profile Republicans to abandon his campaign. He trails Clinton in both national polls and must-win battleground states.

Trump has responded with a scorched-earth strategy that makes him an even more unpredictable foe. With little left to lose, he’s attacked both Clinton and fellow Republicans with a simmering fury that could both enliven his core supporters and turn off undecided voters.

Clinton, meanwhile, must wrestle with whether to confront Trump at Wednesday’s debate in Las Vegas, just as she did in the second debate to mixed reviews, or make a broader statement about her vision for the presidency. Her pivot to red-state voters — the campaign said this week that it was intensifying efforts in Arizona and other conservative states — adds another wrinkle to her debate strategy.