However, those who lost weight from middle to late adulthood had a significantly increased mortality risk.
"In the study reported here, stable obesity and weight loss from an obese to a non-obese pattern from middle to late adulthood had a 20% and 30% higher mortality risk respectively," the team wrote.
They noted weight gain in young adulthood and weight loss in middle adulthood were particularly associated with a high risk of death from heart disease. They didn’t find any apparent associations between weight changes and cancer.
The scientists acknowledged they did not evaluate whether weight loss later in life was intentional or not. Unintentional weight loss could be due to diabetes or cancer, they said.
However, they concluded, “the findings imply that maintaining normal weight across adulthood, especially preventing weight gain in early adulthood, is important for preventing premature deaths in later life.”
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