The researchers stressed that the study’s results only demonstrated an association, not a cause-and-effect relationship, and that clinical trials would be necessary to explore the association further.
The study, published Monday in JAMA, studied the increased dementia risk for elderly patients using proton pump inhibitors, known as PPIs. The drugs examined in the study included omeprazole, pantoprazole, lansoprazole, esomeprazole and rabeprazole, which includes popular brands such as Prilosec, Nexium, and Prevacid. A pool of over 73,000 patients, age 75 and over, were analyzed for the study. Germany's largest health insurer provided the data used in the study.