The region is still struggling with unemployment around 8.6 percent and falling residential real estate prices.
But some experts say Atlanta has already overcome the worst of the rough ride.
Mark Vitner, a senior economist with Wells Fargo, applauded the strategy of improving on the region's assets and focusing more on expansions. But he said the region is in a "frustratingly slow economic recovery" rather than the depressing doldrums of a crisis.
"This is a challenging economic environment for everybody. But it feels a lot worse when you're used to leading the country in nearly every economic statistic," said Vitner. "Atlanta for the longest time was the number one market for new job creation and relocation. And we've been stuck in a huge funk for the last 15 years."
The chamber is casting the next few months as a pivotal point in the future of Georgia's economic engine.
It unveiled its plan a month before residents vote on a one-percent sales tax to fund transportation projects. The chamber has long said the referendum would jump-start the economy and help the region compete with rivals in Texas and North Carolina, but officials said the July 31 vote is only a piece of the overall package.
They said the region's economic trend can be reversed and that following a strategy developed over nine months by Boston Consulting Group could make Atlanta one of the top three U.S. metro areas in job creation over the next decade.
It includes a new focus on developing"sub-clusters," such as wireless telecommunications and health care information, that have already taken root in Atlanta.
"The old model of, 'Let's spend most of our time trying to get companies to relocate here,' is not a bad model, and we need to continue to do that," said John Brock, the chief executive of Coca Cola Enterprises. "But we need to put in place an ecosystem in metro Atlanta that's all about job creation from new metro Atlanta startups."
The campaign will be costly. Williams estimates it will cost at least $30 million, to be raised by business and community leaders. But he and other supporters say it's pivotal for Atlanta's future. "If we don't leverage what we have available, we will get left behind," said Paul Bowers, the chief executive of Georgia Power.
Highlights of the chamber's plan:
1.) Spark short-term and medium-term growth by passing the transportation referendum and concentrating on growth from existing companies and startups in niche industries, such as wireless mobility and health information.
2.) Forge new ties with universities to boost startups and grow venture capital programs to attract new investment.
3.) Advocate for Port of Savannah expansion and ensure completion of long-term reservoir projects.
4.) Market Atlanta as a "top university city" and launch a campaign to tell the city's story across the region and country.
5.) Work with universities to strengthen missions for new business startups and create new investment paths to fund the companies.
Metro area unemployment rates (April)
(not seasonally adjusted)
Tampa-St. Petersburg 8.5