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“Dementia is one of the major health challenges of the 21st century that could threaten successful aging of the population,” Andrew Steptoe, a study co-author and professor of psychology and epidemiology at University College London told CNN. “Our findings suggest that rising obesity rates will compound the issue.”
Researchers established a patient’s dementia status through a doctor’s diagnosis or hospital records and the BMI findings were a standard ratio of height and weight measurements.
Those behind the study also controlled or potential confounding variables such as hypertension, diabetes, smoking. That also included a genetic risk factor for dementia: APOE ε4 gene carrier status. On average, participants who developed dementia were 71.8 years old when they began the study. People who did not have dementia were an average of 61.9 years old when they started the study.
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Previous research pointed to two reasons for the association between dementia and obesity. One possibility is that dementia is directly linked to hormones that come from fat cells. Another is that body fat could be linked to metabolic and vascular pathways tied to the buildup of amyloid proteins or brain lesions, which are known to be associated with dementia.
"Both BMI and waist circumference status should be monitored to avoid metabolic dysregulations," senior author Dr. Dorina Cadar told the news outlet. A senior fellow at UCL's Institute of Epidemiology & Health, Cadar suggested losing weight by cutting back alcohol, exercising regularly and adhering to healthy eating such as following the Mediterranean diet.