Both players had an extended opportunity to play with Josh Allen sitting out the preseason opener and Mitchell Trubisky playing for just two possessions.
The Bills, coming off their first AFC East title since 1995 and longest playoff run in 27 years, clearly want to keep key players healthy for Week 1 in just under a month.
Webb was 11 of 16 for 90 yards and ran twice for 26 yards.
Fromm entered in the fourth quarter and finished 8 of 13 for 65 yards.
“The thing with Jake is, he has been there before,” Buffalo coach Sean McDermott said. “He’s been in big games before, those moments.”
Jared Goff got off to a rough start in his and coach Dan Campbell's debut with the Lions, nearly throwing an interception on his first snap and getting sacked to end the game-opening drive with a thud.
The former Los Angeles Rams quarterback, acquired as part of the Matthew Stafford trade, bounced back with seven straight completions. Goff finished 7 of 9 for 56 yards and had a 4-yard run to set up Randy Bullock’s 28-yard field goal that ended an 18-play, 70-yard drive that took almost 10 minutes off the clock.