Owner Evan Daniell tells the New York Daily News the unusual concoction has been surprisingly popular, "We're selling them left and right. It's a happy accident; it's about being creative."
Daniell estimates he has sold about 150 of the pizzas the last two years.
That's not too bad considering the price, a medium 14-inch Everglades pie goes for $45.
That's because python meat can cost about $66 per pound.
Daniell reportedly has considered creating a "roadkill" pizza, which would include raccoon, armadillo and possum but has had trouble finding a supplier for the specialty meats.