It took firefighters 45 minutes to knock down the fire. Milton Fire Chief Robert Edgar said the house is a total loss.
"The roof is made of cedar shakes and once they're involved in any kind of fire, they just take off," Edgar said. "And we had a strong wind blowing from the north. We had some difficult times."
The fire does not appear to be storm-related, Edgar said. Fire marshals have not determined the cause.
In the morning light, firefighters retrieved some of Wohlers' trophies and memorabilia from a basement room, Edgar said.
The hard-throwing Wohlers debuted with the Braves in 1991. He became the closer in 1995, saving Game 6 of the World Series to clinch Atlanta's only major pro championship.
But in Game 4 of the 1996 World Series, Wohlers gave up the three-run homer to Jim Leyritz that turned the tide for the Yankees.
From 1995 through 1997, Wohlers racked up 97 saves and 282 strikeouts in 211 1/3 innings.
The Braves traded Wohlers to the Reds in 1999, and he retired three years later.
He and his wife run a real estate firm called Team Wohlers.