All four of the officers who resigned previously served under administrations on both sides of the political aisle.
With the resignations, the team joined a growing list of senior foreign service officers who have left the State Department amid the transition to President Donald Trump's administration.
"It's the single biggest simultaneous departure of institutional memory that anyone can remember, and that's incredibly difficult to replicate," David Wade, who served as State Department chief of staff under Secretary of State John Kerry, told The Post. "Department expertise in security, management, administrative and consular positions in particular are very difficult to replicate and particularly difficult to find in the private sector."
Assistant Secretary of State for Diplomatic Security Gregory Starr retired on Jan. 20. On the same day, Lydia Muniz, director of the Bureau of Overseas Building Operations, also left the department.
"That amounts to a near-complete housecleaning of all the senior officials that deal with managing the State Department, its overseas posts and its people," The Post reported.
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The resignations came as Republicans continued working to get Trump's nominee for secretary of state, former Exxon Mobil CEO Rex Tillerson, confirmed to the position. Senate Majority Leader Mitch McConnell, R-Kentucky, said earlier this week he was working toward getting a vote on Tillerson's nomination by next week.
Tillerson has been criticized by detractors who fear his close ties with Russia.