The Paleo regimen consists of protein-heavy, low-carb items, including meats, fish and veggies, and limited fruit. The diet excludes legumes, grains, dairy, refined sugar, salt and processed oils.
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Researchers found that the lack of whole grains was associated with amount of TMAO and “may provide a link between reduced risks of cardiovascular disease we see in populations with high intakes of whole grains,” according to Genoni.
According to the Mayo Clinic, whole grains play an important role in regulating blood pressure and heart health.
Genoni and her colleagues noted the Paleo diet’s increased daily serving recommendation of red meat also provides precursor compounds that produce TMAO—and it encourages more than the recommended level of saturated fats.
The American Heart Association recommends saturated fat make up no more than 5% to 6% of total daily calories (or no more than 11g to 13g if you're following a 2,000-calorie-a-day diet).
Cardiovascular disease is the No. 1 cause of death worldwide. In Australia, heart disease kills one person every 12 minutes. In America, the condition is responsible for 1 in every 4 deaths.