"I do not condone his remarks and cannot defend them. I am grateful that he has expressed remorse and apologized to the American people," Pence said in a statement. "We pray for his family and look forward to the opportunity he has to show what is in his heart when he goes before the nation tomorrow night."
In Georgia, many politicians who were long torn by Trump's rise to the top of the GOP ticket struggled with the fallout of the latest embarrassment.
Ralston said through a spokesman that he was "sickened and disgusted by these reprehensible comments."
"Demeaning and degrading behavior toward women does not reflect the values of the Republican Party to which the Speaker has given a lifetime of service," said Ralston spokesman Kaleb McMichen. "This type of conduct can only contribute to the terrible prospect of a Hillary Clinton presidency. Frankly, in the aftermath of Hurricane Matthew, Georgians have more important things to do today than trying to defend the indefensible."
Isakson, facing pressure from Democrat Jim Barksdale to disavow Trump, said the comments were "wholly inappropriate and unacceptable."
"As a husband, father of a daughter and grandfather to five granddaughters, I am disgusted by Trump’s comments," he added.
Perdue, one of Trump's top national supporters, said through a spokeswoman: “Obviously these comments were disrespectful, and right now Senator Perdue is focused on making sure Georgians are safe and helping our state recover from this major storm.”
And Cagle said it was not "acceptable behavior under any circumstances, adding: "I'm personally sickened by his actions."
At least one high-profile non-elected official announced he would not back Trump. Brennan Mancil, the chairman of the Georgia College Republicans and member of the state party executive committee, said he could not vote for Trump.
"That does not mean I've lost faith in our party," he said, adding that he spent Saturday campaigning for other Republicans on the ballot. "Unless Republican leadership stands up to those who violate every principle of our party, we cannot claim the mantle of conservatism."
Many top Georgia GOP elected officials were torn over Trump's rise long before the latest recorded revelation, but none had publicly disavowed him. Republican state Rep. Allen Peake, R-Macon, came closest with a manifesto warning that Trump-ian policies would lead to the extinction of the Republican Party. But even he said then that he would back Trump over Democrat Hillary Clinton over concerns about her judiciary appointments.
Democratic Party of Georgia executive director Rebecca DeHart seized on the chance to criticize GOP officials for sticking by Trump.
“Where’s the leadership?” she said. “Why haven’t Senators Johnny Isakson and David Perdue and the rest of their Party condemned their candidate and immediately withdrawn their support?”
More AJC coverage of the fallout of Trump’s remarks: