The President had come to Louisiana three times for rallies, fully embracing the battle to knock off Edwards.
While Democrats celebrated the second direct voter rebuke of Mr. Trump in two weeks, Republicans downplayed the results.
"He was going to own the losses either way," said GOP strategist Liam Donovan on Sunday morning. "Not sure any of it mattered all that much in the end in either direction."
In his campaign stops, and on Twitter, the President had cast the more conservative Edwards as a radical liberal, not worthy of the votes of the Bayou State.
"If you want to defend your values, your jobs, and your freedom, then you need to REPLACE Radical Liberal John Bel Edwards with a true Louisiana Patriot," Mr. Trump said on Twitter before the vote.
But while Eddie Rispone led Edwards for much of the night, the late arriving results from Baton Rouge, New Orleans, and the suburban areas of those cities spelled doom for the President.
It was a familiar formula which has led to GOP losses in once-reliable GOP suburbs in cities all over the country: Houston, Dallas, Atlanta, Minneapolis, Chicago, Detroit, Philadelphia, Oklahoma City, Los Angeles, and more.
"Hey are these Trump rallies definitely helping the Republicans?" asked Sen. Brian Schatz (D-HI) on Twitter as the returns rolled in.
Democrats will find out that answer for 2020, in 50 weeks.