Gio Bernard, Cincinnati RB

He’s clearly been the better back through the first games, and if the Bills bring a heavy dose of blitzes, Bernard could have a lot of chances to make plays as a receiver on check-down throws.

Marvin Jones, Cincinnati WR

The last time he lined up against a Rex Ryan-coached defense, Jones caught eight passes for 122 yards and four touchdowns in 49-9 rout of the Jets in 2013.

Rey Maualuga, Cincinnati LB

Whether quarterback Tyrod Taylor plays or not, look for the Bills, who rank sixth in the NFL in rushing, to rely heavily on the ground game. Maualuga will have a big say in how effective that game plan is.

Bacarri Rambo, Buffalo S

Bills coach Rex Ryan has not been pleased with the play of his safeties, and after starter Aaron Williams was lost to a neck injury earlier in the week, Rambo will step in against the league’s No. 2-ranked offense.

Sammy Watkins, Seattle WR

He’s the missed the last two weeks with a calf injury but appears ready to return, and his explosive playmaking abilities could be a problem for a Bengals secondary with nagging injuries of its own.

Mario Williams, Buffalo DE

He has seven sacks in his last nine home games, where the boisterous Buffalo crowd creates problems for opposing offense. And he’ll be working against Andre Smith, who is dealing with an elbow issue.