Falcons CB Desmond Trufant vs. 49ers WR Michael Crabtree: Trufant made his second interception last week and a had a key pass breakup to preserve the 27-26 victory over Washington. Trufant has set a club rookie record and leads the team with 16 passes defensed. After six months of rehabilitating his Achilles, Crabtree scored his first touchdown last week in the third game of his comeback. He had a season-high five catches for 45 yards in the 33-14 win over Tampa Bay. He scored on a 4-yard touchdown pass.

Falcons LT Lamar Holmes vs. 49ers OLB/DE Aldon Smith: Holmes has been battling through what's essentially been his rookie season in the league. While he's played better, he needs to show that he handle an elite rusher for an entire game. Smith led the attack as the 49ers had four sacks against the Bucs last week. Smith had four tackles and two sacks, his 12th multi-sack game. He missed five games earlier this season on a voluntary leave of absence. In 41 career games, Smith has 42 sacks.

Falcons RB Steve Jackson vs. 49ers ILB Patrick Willis: Jackson had two rushing touchdowns against Washington. Jackson has scored five rushing touchdowns over the past four games. He's rushed 128 times for 449 yards after missing four games earlier season with a severe hamstring injury. Willis is one of the game's premier enforcers. He has 80 tackles (63 solos, 17 assists), three sacks and two forced fumbles.