The Falcons were forced to juggle their starting lineup against the Saints because of injuries and performance.
Falcons second-year wide receiver Russell Gage will start for Julio Jones and tight end Jaeden Graham will start at tight end for Luke Stocker because of injuries.
Guard Wes Schweitzer is slated to start at right guard for Jamon Brown because of performance.
Gage, who shined on special teams last season as a rookie, has caught 25 passes for 233 yards this season. Jones, who suffered a AC joint sprain against the Bucs on Sunday, is the Falcons leading receiver with 64 catches for 950 yards and four touchdown.
Stocker has a back injury.
Also, tight end Carson Meier was added to 53-man roster from the practice squad on Wednesday.
Defensive end Austin Larkin, who played 11 special teams snaps against Tampa Bay, was signed to practice squad.
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