Megabus president Dale Moser said Atlanta is a good market for the bus service as a large destination hub city. He said people in Atlanta who have tried Megabus in other parts of the country or have family and friends who have used it have "been tweeting us and blogging us for some time now wondering when we were coming there."
The service is popular among young professionals, 30- to 55-year old women and retirees, he said.
"This is giving them a much more affordable alternative to driving," Moser said. "People are willing to go eight hours on a bus to go someplace for an affordable price."
The firm will go up against recently-launched Greyhound Express service, which goes to nine cities from Atlanta with plans to add two more markets next week.
Megabus estimates it will transport about 400,000 visitors to Atlanta a year, worth about $20 million to the regional economy.
Not all of Megabus' launches have been successful. The company launched service on the West Coast in 2007 but discontinued the service in 2008.