Ryan Newman finished 15th in his first race since suffering a head injury in a last-lap crash in the Daytona 500.
Matt Kenseth, who came out of retirement to replace fired Kyle Larson at Chip Ganassi Racing, finished 10th. The 48-year-old Kenseth raced in the Cup Series for the first time since the 2018 season finale. He was the oldest driver in the field.
This was the first of 20 races across seven Southern states between now and June 21. Darlington will host two more NASCAR races over the next three days.
The first race back was deemed The Real Heroes 400 and was dedicated to health-care workers.