Tech’s Dalton Smith pitched 3 1/3 scoreless innings, allowing just one hit and striking out four.
Vanderbilt starter Jack Leiter (9-3) struck out 11 in six innings. He gave up one earned run and three hits.
Georgia Tech has played nine one-run games in its last 13, winning six of them.
Georgia Tech plays Indiana State Sunday at 3 p.m. in an elimination game in a rematch against Indiana State.
The Jackets used a seventh-inning rally to climb back from a 6-2 deficit to win 7-6 over Indiana State in their opening game of the regional at Hawkins Field on Friday afternoon.