Boston College (3-2, 0-1 ACC)

Next game: at N.C. State, 3:30 p.m. Saturday, FSSO

Huddle up: QB Tyler Murphy and N.C. State QB Jacoby Brissett were teammates at Florida. … Boston College ranks sixth in the FBS in fewest penalties, with an average of four per game. … Starting CB Bryce Jones, who ranked fourth with 20 tackles, was dismissed from the team late last week. John Johnson is listed as a starter at that position. … BC ranks fifth in the FBS at 316.8 yards rushing, but 121st in passing (133.2).

Tweetable fact: Saturday's game will be Boston College's first outside Massachusetts this season.

Clemson (3-2, 2-1)

Next game: vs. Louisville, 3:30 p.m. Saturday, ESPNU

Huddle up: Three freshmen — Wayne Gallman (Grayson), Adam Choice (Thomas County Central) and Deshaun Watson (Gainesville) — combined for 37 carries for 176 yards against N.C. State. … This is the first game between Clemson and Louisville. … CB Martin Jenkins (Centennial) might return from an ankle injury. RT Joe Gore (appendectomy) and WR Charone Peake (knee) are still out. … K Ammon Lakip (Chattahoochee) is 7-of-8 on FG attempts at home this season.

Tweetable fact: Deshaun Watson leads the FBS in yards per attempt (11.2) and ranks second in pass efficiency (197.6).

Duke (4-1, 0-1)

Next game: at Georgia Tech, 12:30 p.m. Saturday, WUPA

Huddle up: At least 10 players missed practice time after coming down with hand, foot and mouth disease. Coach David Cutcliffe had the locker room scrubbed. All of the players are expected to play Saturday. … WR Jamison Crowder needs three catches to move past former Wake Forest WR Michael Campanaro and into fourth on the ACC's career receptions list. Crowder has 227 catches. … Duke has scored in 18 of the 20 quarters it's played this season.

Tweetable fact: Duke has lost 10 consecutive games to Tech and hasn't won at Bobby Dodd Stadium since 1994.

Florida State (5-0, 3-0)

Next game: at Syracuse, noon Saturday, ESPN

Huddle up: Leading receiver Rashad Greene (Westover), who has a concussion, and rusher Karlos Williams (ankle) could miss Saturday's game. Also, C Austin Barron (arm) is out. .. LB Terrance Smith (Southwest DeKalb) will return after a one-game suspension for a violation of team rules. … ACC LB of the week Reggie Northrup had eight tackles and returned a fumble for a TD. … FSU had 11 tackles for loss against Wake Forest, half of its total entering Saturday's game.

Tweetable fact: K Roberto Aguayo has outscored 10 of FSU's 19 opponents in his career.

Louisville (5-1, 3-1)

Next game: at Clemson, 3:30 p.m. Saturday, ESPNU

Huddle up: S Gerod Holliman leads the FBS in interceptions with six picks in five games. … Louisville leads the FBS in total defense (230.2 yards), rushing defense (58.3), interceptions (12) and third-down conversions (23.1 percent). … WR DeVante Parker (foot) might play against Clemson. He missed the first six games. … QB Will Gardner (Coffee), who is coming off a knee injury, practiced and could start.

Tweetable fact: Louisville is the third team in the past decade to open a season allowing 300 yards or fewer in its first six games, joining LSU and Alabama.

Miami (3-3, 1-2)

Next game: vs. Cincinnati, noon Saturday, FSSO

Huddle up: QB Brad Kaaya is one of 17 QBs in the FBS and one of two freshmen to throw for more than 1,500 yards and at least 10 TDs. … RT Taylor Gadbois (East Paulding) could return in a few weeks from a knee injury, but backup Kc McDermott (knee) might be out for a while. Neither has played since a win over Duke on Sept. 27. … Miami has won 11 of the past 12 games against Cincinnati.

Tweetable fact: RB Duke Johnson needs 16 yards to pass Clinton Portis (2,523) for fourth on the school's career rushing list.

North Carolina (2-3, 0-2)

Next game: at Notre Dame, 3:30 p.m. Saturday, NBC

Huddle up: Mistakes are hurting the Tar Heels. They've committed 25 penalties and given up eight sacks in their past two games, both losses. They also fumbled four times in Saturday's loss to Virginia Tech. "We take turns shooting ourselves in the foot right now," coach Larry Fedora said this week. … North Carolina has intercepted at least one pass in every game this season. … DE Mikey Bart (Buford), playing a position called "bandit," has played in all five games, with eight tackles.

Tweetable fact: North Carolina's next seven opponents are a combined 28-11.

North Carolina State (4-2, 0-2)

Next game: vs. Boston College, 3:30 p.m. Saturday, FSSO

Huddle up: QB Jacoby Brissett leads the ACC in TD passes with 13 and hasn't thrown an interception in 174 consecutive attempts, the eighth-longest steak in conference history. … TE Devin O'Connor (Cartersville) is one of four former walk-ons who received a scholarship. … DE Art Norman (Chamblee) is one four captains for Saturday's game. … P Wil Baumann leads the ACC and ranks second in the FBS, with 48 yards per punt.

Tweetable fact: Despite being shut out last week, N.C. State leads the ACC with 27 TDs.

Pittsburgh (3-3, 1-1)

Next game: vs. Virginia Tech, 7:30 p.m. Oct. 16, ESPN

Huddle up: Pitt finalized 2015 games against Youngstown State (Sept. 5), at Akron (Sept. 12), at Iowa (Sept. 19) and Notre Dame (Nov. 7). Pitt and Penn State will resume their series, and the Panthers will play at Oklahoma State and Clemson in 2016. … RB James Conner was held to fewer than 100 yards (83 on 21 carries) for the second consecutive game. He ranks No. 2 in the FBS with 874 rushing yards.

Tweetable fact: After being off this week, Pittsburgh will play consecutive home games against Virginia Tech, Georgia Tech and Duke.

Syracuse (2-3, 0-1)

Next game: vs. Florida State, noon Saturday, ESPN

Huddle up: QB Terrel Hunt will miss 4-6 weeks with a broken fibula. Austin Wilson, who has the most experience, and A.J. Long likely will play in his spot. … Coach Scott Shafer replaced offensive coordinator George McDonald with quarterbacks coach Tim Lester. McDonald will still coach the receivers. … TE Josh Parris (Stephenson) had a season‐high five receptions for 34 yards Saturday. … Syracuse has at least one sack in every game this season.

Tweetable fact: Syracuse will face the reigning Heisman Trophy winner (FSU QB Jameis Winston) for the first time ever Saturday.

Virginia (4-2, 2-0)

Next game: at Duke, 12:30 p.m. Oct. 18, WUPA

Huddle up: Virginia is tied with Georgia Tech for first in the Coastal. … DB Quin Blanding led all ACC players with 15 tackles Saturday. … ACC co-OL of the week C Ross Burbank graded at 93 percent and played every snap. … CB Demetrious Nicholson (turf toe) will miss the remainder of the season. … Coach Mike London said QB Greyson Lambert (Wayne County) could have played Saturday on his injured ankle, but has a bye week to get healthy.

Tweetable fact: Virginia is 2-0 in the ACC for the first time since 2009.

Virginia Tech (4-2, 1-1)

Next game: at Pittsburgh, 7:30 p.m. Oct. 16, ESPN

Huddle up: ACC DL of the week Ken Ekanem had six tackles, three sacks among his four tackles for loss, a forced fumble and two hurries Saturday. … ACC DB of the week Kendall Fuller returned an interception for a score, had four tackles and broke up four passes against UNC. … RB Trey Edmunds led the Hokies with 54 yards rushing, but broke his clavicle and will be out 6-8 weeks.

Tweetable fact: The Fuller brothers who have played at Virginia Tech — Kendall, Vincent, Kyle and Corey — all scored TDs for the Hokies.

Wake Forest (2-4, 0-2)

Next game: vs. Syracuse, noon Oct. 18, FSSO

Huddle up: The offense ranks last in the FBS in rushing with 31 yards per game, and the Demon Deacons couldn't gain more than 130 yards of offense in three of six games. They had minus-26 yards rushing after three quarters in the loss to FSU. … NG Tylor Harris leads the FBS with four fumble recoveries. … John Wolford is tied for the most picks in the FBS (11) and has been sacked more than any other Power 5-conference QB (24).

Tweetable fact: Wake Forest has scored first in all six of its games.