The mission to destroy Syria’s poison gas stockpile was dealt a serious blow Friday when Albania refused to host the destruction, but the global chemical weapons watchdog said it is still confident it can eradicate the arsenal outside Syria by the middle of next year.

The surprise refusal by the small and impoverished Balkan country left open the question of where the Organization for the Prohibition of Chemical Weapons would send Syria’s estimated 1,300-ton arsenal, which includes mustard gas and sarin.

“I can’t name a country at this point, but obviously there are options and there are ways in which this can be accomplished,” senior OPCW official Malik Ellahi said at the organization’s headquarters at The Hague, Netherlands.

Syria has said it wants the weapons destroyed outside the country, which is in the throes of civil war.

Albania had been considered the strongest hope, and few diplomats expected the NATO country of 2.8 million people to reject what Prime Minister Edi Rama said had been a direct request from the U.S.

But the plan was unpopular in Albania, and young protesters had camped outside Rama’s office to oppose it, fearing it would be a health and environmental hazard.

Chemical weapons have to be incinerated at extremely high temperatures or neutralized using other chemicals — both costly, risky and time-consuming operations that require specialized machinery.

In a televised address from the capital of Tirana, Rama said that it was “impossible for Albania to take part in this operation” — an announcement that brought a loud cheer from some of the 2,000 protesters.

Rama said he rejected the request because other countries, which he did not identify, were not prepared to be a part of the operation.

The OPCW’s Ellahi said: “It was a sovereign decision that Albania has taken.”

In Washington, State Department spokeswoman Jan Psaki said the decision would not hurt U.S.-Albanian relations.

“We appreciate Albania looking seriously at hosting the destruction of chemical weapons,” she said. “The international community continues to discuss the most effective and expeditious means for eliminating Syria’s chemical weapons program in the safest manner possible.”

Albania is one of only three nations that have declared a chemical weapons stockpile to the OPCW and destroyed it. The U.S. and Russia have also declared stockpiles but have not yet completed their destruction.

Tirana has been an avid supporter of Washington since the U.S. and NATO intervened with airstrikes in 1999 to stop a crackdown by Serb forces on rebel ethnic Albanians in neighboring Kosovo.

“Without the United States, Albanians would never have been free and independent in two countries that they are today,” Rama said in an apologetic speech.

But the relationship was not enough to convince the hundreds of protesters.

“We don’t have the infrastructure here to deal with the chemical weapons. We can’t deal with our own stuff, let alone Syrian weapons,” said 19-year-old architecture student Maria Pesha, among the protesters camped out overnight outside Rama’s office. “We have no duty to obey anyone on this, NATO or the U.S.”