Body camera video shows Volusia County deputies and Edgewater police, along with other first responders, had only seconds to react.
The video shows officers putting their own lives at risk to rescue the victims, using a punch to break a window of the sedan to get one victim out.
As thick smoke poured from the vehicle, one of the officers tried to open the passenger-side door. After they became overcome by smoke, they went back to the driver's side.
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As the flames started getting bigger, deputies used a knife to cut the airbag out of the way.
Another part of the video shows an officer trying to crawl inside the burning car while his lungs are overcome by smoke.
After making sure everybody was out of the sedan, the officers didn’t stop. They ran to another vehicle, busting out the windows.
The rescuers were able to get the driver out of that second vehicle, but it wasn't easy.
All southbound lanes of I-95 in Volusia County reopened just over 12 hours after the fatal crash, according to the Highway Patrol.
FHP officials said the incident occurred when a man driving the wrong way on southbound I-95 in Volusia County crashed head-on into the SUV.
The wrong-way driver later died of his injuries, the FHP said.
The FHP identified the man who died as 23-year-old Devon Standish, of Daytona Beach.
The crash also triggered a second accident when a UPS truck slowed while coming upon the wreck and was struck by a dump truck hauling asphalt that failed to slow down, troopers said.
The asphalt truck then overturned, spilling hot asphalt across the highway, the FHP said. Troopers said the dump truck driver suffered serious injuries and the UPS driver had minor injuries.
>> Watch the video here. (WARNING: This video has been condensed and edited, but it still contains intense footage and audio.)
The crashes, which happened just before 1 a.m., were the first of two fatal accidents on highways in Volusia County overnight causing delays during Thursday's morning commute.
The morning's other deadly crash happened two hours later, around 2:45 a.m., on Interstate 4 eastbound. Troopers said the crash happened near Exit 108 at Dirksen Drive/Debary Avenue.
Montes said a tow truck driver was merging back onto I-4 eastbound after loading on a vehicle involved in an earlier crash when it was rear-ended by an SUV.
Montes said the driver of the SUV, identified as 35-year-old Adolfo Lopez of Deltona, died at the scene and that the tow truck driver and passenger were transported to the hospital with minor injuries.