The new deliveries are scheduled for 2015 through 2017.
Airbus said many of the A321s for Delta will be assembled in Mobile, where Airbus is building a $600 million plant.
Delta already holds orders for 100 Boeing 737-900s and has hundreds of Boeing aircraft in its fleet. But the announcement Wednesday was a rare win for Airbus over Boeing.
“This order marks a strong return to Airbus since Delta’s last order some two decades ago,” the France-based aircraft maker said in a written statement.