Flights at other airports along the Eastern seaboard could also be delayed and canceled, "depending on the track and severity of the storm," Delta said.
The airline is moving some planes away from New York and Boston ahead of the storm to allow a quick restart of operations after it passes. Planes left in a storm can require lengthy deicing before they can fly again, causing delays.
Atlanta-based Delta also canceled some flights to Myrtle Beach and Charleston, S.C. on Wednesday.
For those whose flights could be affected by the winter weather, Delta is waiving certain change fees for travelers with flights booked Wednesday or Thursday to, from or through certain airports in the Southeast including coastal airports in Georgia and certain airports in the Mid-Atlantic, or booked Thursday or Friday to, from or through certain airports in the Northeast.
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Delta Air Lines is canceling more than 400 flights in New York and Boston due to a Nor'easter.