Atlanta United and Club America have played once before: The Five Stripes defeated Los Aguilas for the Campeones Cup at Mercedes-Benz Stadium last year.
Club America, founded in 1916, is one of the biggest clubs in the Western Hemisphere with 13 league titles and seven Champions League titles.
It is first in the Clausura portion of the LIGA MX schedule with a 5-1-1 record.
Champions League schedule
Tuesday, Feb. 18
Portmore (Jamaica) 1, Cruz Azul (Mexico) 2
Leon (Mexico) 2, Los Angeles (United States) 0
Motagua (Honduras) 1, Atlanta (United States) 1
Wednesday, Feb. 19
Alianza (El Salvador) 2, Tigres (Mexico) 1
Saprissa (Costa Rica) 2, Montreal (Canada) 2
Comunicaciones (Guatemala) 1, America (Mexico) 1
Thursday, Feb. 20
San Carlos (Costa Rica) 3, New York City (United States) 5
Olimpia (Honduras) 2, Seattle (United States) 2
Tuesday, Feb. 25
Atlanta (United States) 3, Motagua (Honduras) 0, Atlanta advanced on 4-1 aggregate
Cruz Azul (Mexico) 4, Portmore (Jamaica) 0, Cruz Azul advanced on 6-1 aggregate
Wednesday, Feb. 26
New York City (United States) 1, San Carlos (Costa Rica) 0, New York City advanced on 6-3 aggregate
Montreal (Canada) 0, Saprissa (Costa Rica) 0, 2-2 aggregate; Montreal advanced on 2-0 away goals
Tigres (Mexico) 4, Alianza (El Salvador) 2, Tigres advanced on 5-4 aggregate
America (Mexico) 1 Comunicaciones (Guatemala) 1, 2-2 aggregate; America advanced on penalties 5-3
Thursday, Feb. 27
Los Angeles (United States) vs. Leon (Mexico), 10 p.m.
Seattle (United States) vs. Olimpia (Honduras), 10 p.m.