German police investigating the apparent role of co-pilot Andreas Lubitz in the crash of Germanwings flight 4U9525 in the French Alps said they made a potentially "significant" discovery while searching his home near Dusseldorf, reports said.

The development comes amid reports in the German media that Lubitz, 27, may have suffered from depression.

"We have found something which will now be taken for tests. We cannot say what it is at the moment but it may be very significant clue to what has happened," Markus Niesczery, a spokesman for Dusseldorf Police, told the Daily Mail late Thursday.

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