Pictures show the front of one of the 18-wheelers was completely destroyed.
Crews had to use a mechanical broom to sweep up the glass from the bottles.
No injures have been reported and the cause of this crash is under investigation.
It's not the first time a crash has left an Arkansas roadway covered in food or drinks, KATV reports.
A crash in August left a truckload of spaghetti sauce at U.S. 278 and Arkansas 24. Earlier that month, a tank car filled with bourbon crashed on I-40 in eastern Arkansas.
The same month, Interstate 30 in Little Rock was shut down after an 18-wheeler crashed and left frozen pizza scattered on the roadway.