Three people were killed and 22 were injured in a crash involving a passenger bus and three other vehicles early Sunday on a New Mexico interstate, the Sandoval County Sheriff’s Office said.

The crash, which involved the bus, a semi trailer, a passenger vehicle and a pickup truck, closed I-25 in both directions, KOAT reported.

The interstate was closed north of Bernalillo after the vehicles collided around 2:25 a.m. Sunday, according to the Rio Rancho Fire Department.

Thirty-eight people were treated at the scene, KOB reported. Of the 22 people taken to the hospital, four were in critical condition, KOAT reported.

The bus overturned on the northbound lane of the interstate, Rio Rancho Fire Battalion Chief Richard Doty told KOAT. The driver of the semi was removed from his vehicle, Doty said.

The number of injuries is unknown.

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