The airline is also suspending flights from New York to Tel Aviv from March 14-24.
The announcement comes a day after Delta said it was suspending its Atlanta to Rome route, after previously reducing the number of flights and suspending some other services to Italy.
Delta said passengers whose flights are affected can rebook on alternate flights, get refunds or contact the airline to discuss other options.
Flights between New York and Milan on Delta are suspended until May 20. The last Delta flight from Milan to New York operated March 3.
Other cuts include delaying the launch of summer season flights, which typically begin April 1, from from Detroit to Rome until May 1 and from New York to Venice until May 21.
There have been more than 9,100 cases of COVID-19 reported in Italy.
The Centers for Disease Control and Prevention is advising travelers to avoid non-essential travel to Italy and the State Department has raised its travel warning to "do not travel" to the regions in Italy most affected by coronavirus.
The State Department issued a do not travel advisory for Lombardy, where Milan is the capital, and Veneto.
Passengers coming to the United States from Italy and South Korea are being screened.
Delta waived change fees for bookings to Italy, China and South Korea before announcing it was suspending flights to China and reducing flights to Korea and Italy.
A change fee waiver allows travelers to avoid flying to areas with coronavirus outbreaks or avoid the risk that the airline may cancel the flights.