As a runner, Vick blazed through 3,859 yards and 21 touchdowns as a Falcon. In 2006, he became the first - and only - quarterback in the NFL to rush for more than 1,000 yards in a season.
The Falcons released him in 2009 after failing to trade him. He went on to play for the Philadelphia Eagles, N.Y. Jets, and Pittsburgh Steelers.
Vick, 36, told ESPN's Josina Anderson he was retiring.
In a statement to ESPN, he said:
"I think it's time.
"So now I think I'm officially ready, I'm ready to move on to different things in my life and different facets of my life."
Vick recently penned a letter to Atlanta looking back at his time in in the city. He had previously said he would like to retire a Falcon.