The basset hound had suffered from lymphoma over the past year. When its conditioned worsened, Drummond said she decided to have the dog put to sleep.
Many took to Twitter to tell Drummond about the dog's impact on their families.
In a post on her website, Drummond said she will allow parents to decide whether or not to tell their children about Charlie's death.
"It might not be necessary if they are younger!" she added.
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Drummond is the television personality behind Food Network's "The Pioneer Woman," which stems from her longtime blogging about ranch life and Southern living.
She recently opened The Mercantile in Pawhuska, Oklahoma, where she lives.