The S&P 500 fell 3.37 points to 4,226.52. The Dow lost 126.15 points, or 0.4%, to 34,630.24. The Nasdaq rose 67.23 points, or 0.5%, to 13,881.72. The Russell 2000 index of smaller companies gained 32.76 points, or 1.4%, to 2,319.18.
Banks, industrial stocks and materials companies helped pull the broader market lower. Communications companies and health care stocks made solid gains. Facebook rose 1.9%, while drugmaker Moderna rose 6.6% after it sought regulatory authorization in Europe to let adolescents receive its COVID-19 vaccine.
Biogen soared 38.3% for the biggest gain in the S&P 500 after the Food and Drug Administration said it approved the company’s drug for treating Alzheimer’s disease. Biogen’s drug is the first Alzheimer’s disease treatment approved by the FDA in nearly 20 years.
Treasury yields mostly rose. The yield on the 10-year Treasury inched up to 1.57% from 1.56% late Friday. Crude oil prices were little changed.
Cruise line operators rose after several companies announced or confirmed plans to start sailing again this summer. The industry essentially shut down during the virus pandemic. Norwegian Cruise Line added 3.1% and Carnival rose 1.1%.
Corporate buyout plans moved several stocks. U.S. Concrete jumped 29.3% after construction materials company Vulcan Materials said it would buy the company. Design software company Autodesk fell 2.1% after announcing plans to pursue a buyout of Altium.
Investors will get another glimpse into the impact of inflation on Thursday with the Labor Department’s consumer price report for May. Prices on everything from food to clothes and housing has been rising as the economy recovers.
Investors and economists are concerned that a steep rise in prices could crimp the recovery and prompt the Federal Reserve to withdraw some of its support for the economy such as keeping interest rates ultra-low and buying bonds.
Markets in Europe closed mostly higher, while Asian markets ended mixed.