The canceled flights were scheduled to leave after 5 p.m., when the snow is expected to move in.
The airline said it would waive certain change fees for affected passengers.
It also has encouraged travelers on those scheduled flights to switch to an earlier flight on Thursday.
The airline said reservation agents are “proactively contacting customers to make adjustments to flight plans.”
Delta is allowing customers to make a one-time change to their travel plans if they are flying into or out of Atlanta and the following states: Alabama, Arkansas, Mississippi and Tennessee.
AirTran has cancelled 51 flights nationwide. It also is offering impacted travelers the option of changing their plans without penalty.