Witnesses told deputies that someone started shooting at the party from a car while driving down the road, and that people at the party exchanged gunfire, Fox Carolina reported.
The victims were transported to hospitals in Spartanburg, Cherokee and Union counties, according to Fox Carolina.
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The families of the deceased had not been notified as of late Saturday, Coroner William Holcombe told the news station.
A few suspects were detained and one was arrested, Coffer told Fox Carolina.