- Loeffler is not a favorite of the conservative wing of Georgia's Republican Party. When her name surfaced as a contender for Isakson's seat, critics circulated screen shots of past donations to Democrats, as well as more recent contributions from her company's political action committee.
- They also contrasted her support for Republican Mitt Romney's presidential campaign in 2012 – when she gave $750,000 to the candidate's PAC – with her lack of financial support for Trump's 2016 campaign for the White House. She has since ponied up to his campaign, including a $100,000 gift to participate in Trump's Nov. 8 roundtable in Atlanta.
- Loeffler is the CEO of the financial services firm Bakkt and a co-owner of the Atlanta Dream, the city's WNBA franchise.
- She used to be the chief communications and marketing officer and head of investor relations for the Atlanta-based Intercontinental Exchange, a financial trading platform that owns the New York Stock Exchange. Intercontinental Exchange was founded by Loeffler's husband, Jeff Sprecher.
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