The research was done on rats.

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The drug changed the way fat was metabolized and triggered extreme inflammation and a corresponding sharp rise in the formation of ceramides; those are the molecules that cause cells to age and die.

“We found this signaling process to be key for advanced cellular aging, which is at the heart of the accelerated aging influenced by methamphetamine abuse,”Piomelli said.

Methamphetamine is highly addictive drug, in part because it gives users a feeling of euphoria.

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Angie McBrayer, ex-wife of James Aaron McBrayer, leans her head on her son Sam McBrayer as she and her three children and two grandchildren (from left) Jackson McBrayer, 3, Piper Jae McBrayer, 7, Katy Isaza, and Jordan McBrayer, visit the grave of James McBrayer, Thursday, November 20, 2025, in Tifton. He died after being restrained by Tift County sheriff's deputies on April 24, 2019. His ex-wife witnessed the arrest and said she thought the deputies were being rough but did not imagine that McBrayer would die. (Hyosub Shin/AJC)

Credit: HYOSUB SHIN / AJC