60 votes were needed to force an end to debate on a motion to start work on the Coronavirus bill. Republicans only mustered 47.
Republicans were left more than frustrated, as GOP Senators said now was the time for action, not more negotiation and debate.
"The American people are watching this spectacle," said a furious Senate Majority Leader Mitch McConnell, who denounced Democrats for 'playing games' by not agreeing to move forward with the GOP bill.
"The Senate must step up," said Sen. Kelly Loeffler (R-GA). "It is time to deliver."
“I hope the Senate can act fast on something,” said Sen. Marco Rubio (R-FL).
Republicans were hamstrung somewhat by the absence of five GOP Senators, because of Coronavirus concerns.
On Sunday morning, Sen. Rand Paul (R-KY) tested positive for the Coronavirus - though he had no symptoms of any illness.
That prompted two other Senators, Mitt Romney and Mike Lee, to go into self quarantine, joining Sen. Rick Scott (R-FL), and Sen. Cory Gardner (R-CO).
It was not immediately clear what would happen next in the Senate.
“It is unbelievable that Democrats would stall the relief bill,” said Sen. James Lankford (R-OK).
“We're fiddling here,” said Sen. McConnell, as he all but accused House Speaker Nancy Pelosi of ruining talks for a deal.
“We were doing just fine until that intervention," McConnell said on the Senate floor, visibly irritated.