In combination with aspirin, omega-3 fatty acids could be helpful in the treatment of some forms of coronary artery disease. Consult your healthcare provider about whether this combination would be appropriate for you if you have coronary artery disease.

Omega-3 fatty acids may reduce some of the side effects associated with cyclosporine therapy, which is often used to reduce the chances of rejection in transplant recipients. Consult your healthcare provider before adding any new herbs or supplements to your existing medication regimen.

In an animal study, omega-3 fatty acids protected the stomach against ulcers induced by reserpine and nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin. Consult your healthcare provider before using omega-3 fatty acids if you are currently taking these medications.

EPA has also been shown to boost the effects of a combination of low-dose etretinate and a topical corticosteroid medication used to treat severe, chronic psoriasis. Consult your doctor to determine if this combination therapy may be of benefit for you if you suffer from chronic psoriasis.